Description

Cloticasone Propionate CAS NO 80486-69-7 is a synthetic corticosteroid belonging to the glucocorticoid class, recognized for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced topical and inhalation pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for dermatological conditions such as eczema and psoriasis, as well as respiratory ailments including asthma.

Application

• Pharmaceutical API: Primary active ingredient in topical creams, ointments, and lotions for treating inflammatory skin disorders.
• Inhalation Therapeutics: Key component in metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) for managing asthma and chronic obstructive pulmonary disease (COPD).
• Veterinary Medicine: Used in topical formulations for anti-inflammatory treatment in animals.
• Research & Development: Serves as a reference standard and building block in pharmacological research and new drug development.
• Compounding Pharmacy: Utilized in the preparation of customized medication formulations.

Basic Information

Product Name	Cloticasone Propionate
CAS No.	80486-69-7
Molecular Formula	C25H32ClFO5
Molecular Weight	466.97 g/mol
Synonyms	Cloticasone 17-propionate; Cloticasonum Propionas; Cloticasone Propionate (USAN); UNII-6V05114P8U; 6α,9α-Difluoro-11β,21-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-diene-17-propionate; 6α,9α-Difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-propionate; (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate
EINECS	Contact for details

Quality Control

Our Cloticasone Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.