Description

S-Chlorofluticasone Acetate is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound is a key building block in the synthesis of advanced topical anti-inflammatory medications, offering critical structural specificity for targeted therapeutic activity. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers engaged in the development and production of next-generation dermatological and respiratory treatments.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of potent topical corticosteroids like fluticasone propionate and its analogues.
• API Manufacturing: Serves as a key raw material in the controlled, multi-step production of finished Active Pharmaceutical Ingredients (APIs) for regulated markets.
• Research & Development: Essential for medicinal chemistry research, process development, and the creation of new chemical entities (NCEs) within the corticosteroid class.
• Dermatological Formulations: Used in the development of creams, ointments, and lotions for treating conditions such as eczema, psoriasis, and dermatitis.
• Respiratory Drug Synthesis: Involved in the production pathway for inhaled corticosteroids used in asthma and COPD management.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	S-Chlorofluticasone Acetate
CAS No.	80474-07-3
Molecular Formula	C24H28Cl2F2O5S
Molecular Weight	537.44 g/mol
Synonyms	Fluticasone Impurity F; 6α,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-[(2-thienylcarbonyl)oxy]androsta-1,4-diene-17β-carbothioic Acid S-(Chloromethyl) Ester; S-(Chloromethyl) 6α,9-difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate 17-Acetate; 17-Acetoxy-6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic Acid S-Chloromethyl Ester; S-Chloromethyl Fluticasone Acetate
EINECS	Contact for details

Quality Control

Our S-Chlorofluticasone Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.