Description

Androsta-1,4-Diene-17-Carbothioic Acid, 6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxo-, (6A,11B,16A,17A)- is a high-purity synthetic steroid derivative with a complex molecular structure featuring a carbothioic acid group and multiple halogen and hydroxyl substitutions. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potent corticosteroid analogs and other specialized steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used as a reference standard or starting material in medicinal chemistry programs for developing new anti-inflammatory, dermatological, or respiratory drugs.
• Process Chemistry: Employed in route scouting and optimization studies for the scalable production of complex steroid molecules.
• Biochemical Research: Acts as a ligand or probe in studying steroid receptor interactions and metabolic pathways due to its specific structural modifications.

Basic Information

Product Name	Androsta-1,4-Diene-17-Carbothioic Acid, 6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxo-, (6A,11B,16A,17A)-
CAS No.	80473-92-3
Molecular Formula	C21H24F2O4S
Molecular Weight	410.48 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-Carbothioic Acid; 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic Acid; Fluticasone Impurity; Fluticasone Related Compound; (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid
EINECS	Contact for details

Quality Control

Our Androsta-1,4-Diene-17-Carbothioic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.