Description

n-Maleyldaunomycin is a chemically modified derivative of the anthracycline antibiotic daunorubicin, designed for enhanced research and development applications. This compound is of significant interest in the field of oncology research due to its potential as a key intermediate in the synthesis of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing advanced cancer therapies and studying drug mechanisms.

Application

• Pharmaceutical Intermediate: A critical starting material or intermediate in the synthesis of novel anthracycline-based anticancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action against tumor cell lines.
• Bioconjugation Studies: Serves as a model compound for developing antibody-drug conjugates (ADCs) or other targeted drug delivery systems.
• Academic Research: Employed in university and institutional labs for fundamental research on DNA intercalation and topoisomerase II inhibition.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for related pharmaceutical compounds.
• Process Chemistry Development: Key material for optimizing scalable synthetic routes for complex anthracycline derivatives in pilot and commercial manufacturing.

Basic Information

Product Name	n-Maleyldaunomycin
CAS No.	80445-76-7
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	N-Maleyldaunomycin; Daunorubicin N-maleyl derivative; 3'-N-Maleyl-13-dihydrodaunorubicin; 3'-N-(Carboxyacryloyl)daunorubicin; 3'-N-Maleyl-13-dihydrodaunomycin; 3'-N-Maleyldaunorubicin; Daunorubicin, 3'-N-maleyl-13-dihydro-; 13-Dihydrodaunorubicin 3'-N-maleyl derivative
EINECS	Contact for details

Quality Control

Our n-Maleyldaunomycin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.