Description

(3-Chloro-4-Trifluoromethoxy-Phenyl)-Oxo-Acetonitrile is a high-purity, specialized organic intermediate featuring a unique trifluoromethoxy and chloro-substituted aromatic ring system. This compound is valued for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, where its structural motifs can impart desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development teams in the fine chemical, agrochemical, and pharmaceutical industries for constructing novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key synthon for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy and nitrile groups.
• Pharmaceutical Building Block: Used in the research and synthesis of potential drug candidates, particularly in areas requiring fluorinated aromatic compounds for enhanced potency and pharmacokinetic properties.
• Material Science Research: Serves as a precursor for specialized polymers, liquid crystals, or organic electronic materials due to its rigid, substituted benzene core.
• Chemical Synthesis: Employed in organic chemistry laboratories for constructing complex molecules via reactions at the oxo-acetonitrile functional group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this precise chemical scaffold.

Basic Information

Product Name	(3-Chloro-4-Trifluoromethoxy-Phenyl)-Oxo-Acetonitrile
CAS No.	80277-44-7
Molecular Formula	C9H3ClF3NO2
Molecular Weight	249.57 g/mol
Synonyms	2-(3-Chloro-4-(trifluoromethoxy)phenyl)-2-oxoacetonitrile; 2-Oxo-2-[3-chloro-4-(trifluoromethoxy)phenyl]acetonitrile; (3-Chloro-4-trifluoromethoxyphenyl)glyoxyloyl cyanide; 3-Chloro-4-trifluoromethoxybenzoyl cyanide; α-Oxo-3-chloro-4-(trifluoromethoxy)benzeneacetonitrile; 3-Chloro-α-oxo-4-(trifluoromethoxy)benzeneacetonitrile; Glyoxylic acid cyanide, (3-chloro-4-trifluoromethoxyphenyl)-
EINECS	Contact for details

Quality Control

Our (3-Chloro-4-Trifluoromethoxy-Phenyl)-Oxo-Acetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.