Description

Metoprolol Fumarate is a selective β-1 adrenergic receptor blocker salt form, combining the therapeutic agent metoprolol with fumaric acid for enhanced stability and formulation properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy, safety, and batch-to-batch consistency of cardiovascular medications. It is primarily required by pharmaceutical manufacturers and research institutions developing and producing solid oral dosage forms for the management of hypertension, angina, and heart failure.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of extended-release and immediate-release tablet formulations.
• Hypertension Treatment: Used in medications designed to lower high blood pressure by blocking β-1 receptors in the heart.
• Angina Pectoris Management: Incorporated into drugs that prevent chest pain by reducing cardiac workload and oxygen demand.
• Heart Failure Therapy: A component in treatment regimens to improve survival and reduce hospitalizations in certain heart failure patients.
• Post-Myocardial Infarction Care: Used in secondary prevention medications following a heart attack.
• Pharmaceutical R&D: Serves as a reference standard and raw material in analytical method development and new formulation research.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded metoprolol medications.

Basic Information

Product Name	Metoprolol Fumarate
CAS No.	80274-67-5
Molecular Formula	C34H50N2O12
Molecular Weight	678.77 g/mol
Synonyms	Metoprolol Fumarate Salt; Metoprolol Hydrogen Fumarate; (±)-Metoprolol Fumarate; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol Fumarate; Lopressor Salt; Toprol-XL API; CGP 2175; Betaloc
EINECS	Contact for details

Quality Control

Our Metoprolol Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with major pharmacopeial standards such as USP and EP. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological attributes is provided with every shipment to guarantee regulatory compliance and supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Ensure the storage area is well-ventilated and away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets EP/USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.