Description

Exemestane 16-Methyleneandrost-4-Ene-3,17-Dione CAS NO 80108-48-1 is a potent, irreversible steroidal aromatase inhibitor. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting hormone-dependent conditions. It is primarily required by pharmaceutical manufacturers and advanced research institutions developing oncology and endocrine therapies.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate in the commercial production of the anticancer drug Exemestane.
• Oncology Research: Used in preclinical and clinical research for studying aromatase inhibition and breast cancer treatment mechanisms.
• Endocrine Disorder Therapeutics: Serves as a key building block for developing treatments for estrogen-dependent disorders.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC and LC-MS methods.
• Process Development: Utilized in pharmaceutical R&D for scaling up and optimizing synthetic routes for steroidal drugs.
• Academic & Institutional Research: Fundamental compound for biochemical studies on steroidogenesis and enzyme inhibition.

Basic Information

Product Name	Exemestane 16-Methyleneandrost-4-Ene-3,17-Dione
CAS No.	80108-48-1
Molecular Formula	C20H24O2
Molecular Weight	296.40 g/mol
Synonyms	Exemestane Intermediate; 6-Methylenandrosta-1,4-diene-3,17-dione; Aromasin Intermediate; FCE 24304; 16-Methyleneandrost-4-ene-3,17-dione; 6-Methylenandrosta-1,4-diene-3,17-dione; Androsta-1,4-diene-3,17-dione, 6-methylene-; (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
EINECS	Contact for details

Quality Control

Our Exemestane intermediate is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical synthesis and research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC are available for every batch. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.