Description

6-Alpha,9-α-Difluoro-11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound, with CAS number 807-38-5, serves as a critical building block in the synthesis of potent anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). It is primarily required by advanced pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of advanced corticosteroid APIs such as Difluprednate and related analogues.
• Anti-inflammatory Drug Development: Used in R&D for creating novel ophthalmic solutions and topical formulations targeting inflammation.
• Steroid Synthesis: A fundamental scaffold for medicinal chemists exploring structure-activity relationships in the glucocorticoid receptor agonist series.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for fluorinated steroid products.

Basic Information

Product Name	6-Alpha,9-α-Difluoro-11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
CAS No.	807-38-5
Molecular Formula	C21H26F2O6
Molecular Weight	412.43 g/mol
Synonyms	Difluprednate Intermediate; 6α,9α-Difluoro-11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione; 6α,9α-Difluoroprednisolone 16α,17α-Acetonide Precursor; 9α-Fluoro-6α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione; 6α,9α-Difluoro-δ1-hydrocortisone 16α,17α-acetonide derivative; 807-38-5; NSC 113927
EINECS	Contact for details

Quality Control

Our 6-Alpha,9-α-Difluoro-11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.