Description

6-α-Fluoro-Isoflupredone is a synthetic fluorinated corticosteroid derivative of significant interest in advanced pharmaceutical research and development. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, which are enhanced by the strategic α-fluorination of the isoflupredone structure. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers developing next-generation topical and systemic corticosteroid therapies targeting dermatological, ophthalmic, and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, high-potency corticosteroid APIs.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing treatments for psoriasis, eczema, and dermatitis.
• Ophthalmic Formulations: Investigated for use in eye drops and ointments to treat inflammatory eye disorders.
• Veterinary Medicine: Potential application in developing anti-inflammatory treatments for animals.
• Biochemical Research: A tool compound for studying glucocorticoid receptor interactions and metabolic pathways.
• Reference Standard: Used in analytical laboratories for method development and quality control testing of corticosteroid products.

Basic Information

Product Name	6-α-Fluoro-Isoflupredone
CAS No.	806-29-1
Molecular Formula	C21H27FO5
Molecular Weight	378.44 g/mol
Synonyms	6α-Fluoro-11β,17α,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione; 6α-Fluoroisoflupredone; 6α-Fluoro-16-methyleneprednisolone; 6α-Fluoro-δ1-16-methyleneprednisolone; Fluoro-isoflupredone; 6-Fluoro-isoflupredone
EINECS	Contact for details

Quality Control

Our 6-α-Fluoro-Isoflupredone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.