Description

Pregna-4,16-Diene-3,20-Dione, 9-Fluoro-11Beta,21-Dihydroxy- is a high-purity synthetic steroid intermediate of significant commercial and research importance. This compound serves as a critical building block in the synthesis of potent glucocorticoid and anti-inflammatory pharmaceutical agents. It is primarily sought by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers for the development of advanced corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potent topical and systemic corticosteroids (e.g., derivatives of fluocinolone acetonide).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory drugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in controlled GMP processes for the production of steroid-based APIs.
• Biochemical Research: Serves as a reference standard and tool compound for studying glucocorticoid receptor interactions and metabolic pathways.
• Veterinary Medicine: Potential use in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	Pregna-4,16-Diene-3,20-Dione, 9-Fluoro-11Beta,21-Dihydroxy-
CAS No.	802-71-1
Molecular Formula	C21H25FO4
Molecular Weight	360.42 g/mol
Synonyms	9α-Fluoro-11β,21-dihydroxypregna-4,16-diene-3,20-dione; 9-Fluoro-11β,21-dihydroxypregna-4,16-diene-3,20-dione; 9α-Fluoro-16-dehydroprednisolone; Fluocinolone Acetonide Intermediate; 9-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 16,17-acetonide precursor; 802-71-1; NSC 121773
EINECS	Contact for details

Quality Control

Our Pregna-4,16-Diene-3,20-Dione, 9-Fluoro-11Beta,21-Dihydroxy- is produced and tested under strict quality management systems. We offer material suitable for research and GMP-grade synthesis, with typical purity exceeding 98.0% (by HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications can be tailored to meet USP/EP monograph requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.