Description

Brompheniramine CAS NO 86-22-6 is a potent alkylamine-class antihistamine compound, recognized for its selective antagonism of the H1 receptor. Its primary commercial value lies in its critical role as a key active pharmaceutical ingredient (API) in the formulation of over-the-counter and prescription allergy, cold, and cough medications. This high-purity intermediate is essential for manufacturers in the global pharmaceutical and nutraceutical industries seeking reliable, compliant raw materials for solid-dose, liquid, and injectable formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihistamine tablets, syrups, and sustained-release formulations for allergic rhinitis and urticaria.
• Combination Cold & Flu Medications: Used in multi-symptom relief products combined with analgesics, decongestants, and antitussives.
• Veterinary Pharmaceuticals: Formulated into medications for allergic conditions in companion animals and livestock.
• Clinical Research: Serves as a reference standard and biochemical tool in pharmacological studies of histamine pathways.
• Generic Drug Manufacturing: A fundamental building block for producers of cost-effective generic antihistamine products.
• Controlled-Release Drug Delivery Systems: Incorporated into advanced matrix systems designed for prolonged therapeutic effect.

Basic Information

Product Name	Brompheniramine
CAS No.	86-22-6
Molecular Formula	C16H19BrN2
Molecular Weight	319.24 g/mol
Synonyms	Brompheniramine Maleate (common salt); 3-(4-Bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine; Parabromdylamine; Dimegan; Ilvin; Veltane; Brompheniramine Base; DL-Brompheniramine
EINECS	201-656-7

Quality Control

Our Brompheniramine is manufactured and tested under a strict quality management system. We ensure compliance with major pharmacopoeial standards, including USP-NF and EP monographs, where applicable. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques like HPLC and GC. Our commitment to cGMP principles guarantees consistency and traceability for regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.