Description

Buclizine is a piperazine derivative antihistamine compound with specific pharmacological properties. It is valued for its antiemetic and antiallergic effects, making it a key intermediate in the synthesis of specialized pharmaceutical formulations. This compound is primarily required by pharmaceutical manufacturers and advanced research institutions developing treatments for motion sickness, allergies, and related conditions.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of antihistamine and antiemetic active pharmaceutical ingredients (APIs).
• Antiemetic Drug Development: Research and production of medications aimed at preventing and treating nausea and vomiting, particularly motion sickness.
• Antiallergic Formulations: Used in the development of therapeutic agents targeting allergic reactions and histamine-mediated conditions.
• Veterinary Pharmaceuticals: Potential application in the formulation of veterinary medicines for similar indications.
• Biochemical Research: Serves as a reference standard and a tool compound in pharmacological and biochemical studies investigating histamine H1-receptor antagonism.
• Custom Synthesis: Acts as a starting material or intermediate for the custom synthesis of novel chemical entities and derivatives in medicinal chemistry.

Basic Information

Product Name	Buclizine
CAS No.	82-95-1
Molecular Formula	C28H33ClN2
Molecular Weight	433.03 g/mol
Synonyms	1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine; Buclizine Hydrochloride (salt form); Buclifen; Aphilan; Longifene; Vibazine; Histabutizine; UCB 4445
EINECS	201-445-8

Quality Control

Our Buclizine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets exacting standards for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.