Description

(2S,4R)-4-Fluoropyrrolodine-2-Carboxamide Hcl CAS NO 796884-06-5 is a high-purity, fluorinated pyrrolidine derivative used as a critical chiral building block in advanced organic synthesis. This compound is valued for its unique stereochemistry and fluorine atom, which are essential for modulating the biological activity and metabolic stability of target molecules. It is primarily required by pharmaceutical and biotechnology research organizations for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and neurology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially protease inhibitors and enzyme modulators.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to construct constrained peptide analogs and other bioactive compounds where the fluoropyrrolidine scaffold imparts specific conformational and binding properties.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and probes for studying biological mechanisms and target engagement.
• Process Chemistry & Scale-up: Suitable for use in route development and cGMP manufacturing of clinical trial materials and commercial APIs.

Basic Information

Product Name	(2S,4R)-4-Fluoropyrrolodine-2-Carboxamide Hydrochloride
CAS No.	796884-06-5
Molecular Formula	C5H9FN2O·HCl
Molecular Weight	168.60 (Free base) / 205.06 (HCl salt)
Synonyms	(2S,4R)-4-Fluoropyrrolidine-2-carboxamide hydrochloride; 4-Fluoro-D-prolinamide hydrochloride; (4R)-4-Fluoroproline amide hydrochloride; (2S,4R)-4-Fluoro-L-prolinamide HCl; 4-Fluoro-L-proline amide hydrochloride; 796884-06-5; Fluoropyrrolidine carboxamide HCl
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Fluoropyrrolodine-2-Carboxamide Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.