Description

2-Chloro-4-Fluoro-3-Methylbenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and incorporation into complex molecular architectures. This intermediate is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the chloro-fluoro-methyl motif contributes to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers with specific optoelectronic properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses (CROs/CMOs) to fulfill client-specific molecule requests for drug discovery programs.
• Chemical Biology Probes: Useful for constructing molecular probes and tags used in biochemical assays and diagnostic research.

Basic Information

Product Name	2-Chloro-4-Fluoro-3-Methylbenzonitrile
CAS No.	796600-15-2
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-Chloro-4-fluoro-3-methylbenzonitrile; 3-Methyl-2-chloro-4-fluorobenzonitrile; Benzonitrile, 2-chloro-4-fluoro-3-methyl-; 796600-15-2; 2-Chloro-4-fluoro-3-methyl-benzonitrile; 2-Chloro-4-fluoro-3-methylbenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-3-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.