Description

Abarelix Acetate is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a potent antagonist. This compound is of significant commercial and research interest for its targeted endocrine activity. It is primarily utilized in the pharmaceutical and advanced life science research sectors for the development and production of therapeutic agents.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable hormonal therapies.
• Hormone-Dependent Cancer Research: Used in preclinical and clinical studies targeting conditions such as advanced prostate cancer.
• Endocrinology Studies: A key tool for investigating the GnRH receptor pathway and pituitary-gonadal axis function.
• Therapeutic Agent Development: Serves as a reference standard and building block for developing new GnRH antagonist analogs.
• Biochemical Research: Employed in receptor binding assays and mechanistic studies of peptide hormone action.
• Veterinary Pharmaceutical Applications: Potential use in controlling reproduction in animals.

Basic Information

Product Name	Abarelix Acetate
CAS No.	785804-17-3
Molecular Formula	C72H95ClN14O14 • xC2H4O2
Molecular Weight	1416.06 g/mol (free base)
Synonyms	Abarelix; PPI-149; R-3827; Gonadotropin-Releasing Hormone Antagonist (GnRH Antagonist); Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(L-hydroorotyl)-D-4Aph(Cbm)-Leu-Lys(iPr)-Pro-D-Ala-NH2 acetate; Plenaxis (brand name)
EINECS	Contact for details

Quality Control

Our Abarelix Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, mass spectrometry for identity confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥95.0%
Single Impurity (HPLC)	≤1.0%
Water Content (KF)	≤5.0%
Acetate Content (IC)	3.0% - 8.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.