Description

D-Alanine, 3,3-Difluoro-, Ethyl Ester (9Ci) is a fluorinated derivative of the amino acid alanine, characterized by its specific stereochemistry and the presence of a difluoromethyl group. This compound serves as a valuable, high-purity chiral building block for the synthesis of complex bioactive molecules, offering precise control over molecular structure. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the creation of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the effect of fluorine substitution and stereochemistry on drug potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced, fluorinated pesticides and herbicides, where the difluoro moiety can enhance biological activity.
• Peptidomimetics Development: Incorporated into the design of peptide analogs and mimetics to improve their pharmacological properties and resistance to enzymatic degradation.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological mechanisms and target engagement.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of fluorinated fine chemicals.

Basic Information

Product Name	D-Alanine, 3,3-Difluoro-, Ethyl Ester (9Ci)
CAS No.	773046-41-6
Molecular Formula	C5H9F2NO2
Molecular Weight	153.13 g/mol
Synonyms	Ethyl (2R)-3,3-difluoro-2-aminopropanoate; (R)-Ethyl 3,3-difluoroalaninate; D-3,3-Difluoroalanine ethyl ester; (R)-3,3-Difluoroalanine ethyl ester; 773046-41-6; Alanine, 3,3-difluoro-, ethyl ester, D-; Ethyl (R)-3,3-difluoroalaninate
EINECS	Contact for details

Quality Control

Our D-Alanine, 3,3-Difluoro-, Ethyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and identity are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.