Description

4-Amino-2-Chloro-3-Fluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block with significant synthetic utility. This compound matters as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated and amino-substituted motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogen and amino groups for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and advanced organic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for creating complex colorants and functional dyes.
• Cross-Coupling Reactions: An excellent substrate for Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions.
• Organic Synthesis Research: A versatile reagent for academic and industrial research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	4-Amino-2-Chloro-3-Fluorobenzonitrile
CAS No.	757247-99-7
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	2-Chloro-3-fluoro-4-aminobenzonitrile; 3-Fluoro-2-chloro-4-cyanobenzenamine; 4-Cyano-2-chloro-3-fluoroaniline; Benzonitrile, 4-amino-2-chloro-3-fluoro-; 4-Amino-2-chloro-3-fluorobenzene carbonitrile; 2-Chloro-3-fluoro-4-aminobenzene carbonitrile; 4-Amino-2-chloro-3-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Chloro-3-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.