Description

1-(4-Bromo-2-Fluorophenyl)Cyclopropane-1-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane-carbonitrile scaffold substituted with bromo and fluoro halogens. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing targeted molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the halogenated phenyl group contributes to bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized organic materials, including liquid crystals and organic semiconductors.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)Cyclopropane-1-Carbonitrile
CAS No.	749928-88-9
Molecular Formula	C10H7BrFN
Molecular Weight	240.07 g/mol
Synonyms	1-(4-Bromo-2-fluorophenyl)cyclopropanecarbonitrile; 1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carbonitrile; 4-Bromo-2-fluoro-α-(cyanocyclopropyl)benzene; (4-Bromo-2-fluorophenyl)(cyclopropyl)acetonitrile; Cyclopropanecarbonitrile, 1-(4-bromo-2-fluorophenyl)-; 749928-88-9
EINECS	Contact for details

Quality Control

Our production of 1-(4-Bromo-2-Fluorophenyl)Cyclopropane-1-Carbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.