Description

2-(4-Bromo-2-Fluorophenyl)-2-Methylpropanenitrile is a high-purity, versatile organic building block featuring a bromo-fluorophenyl core. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals. Its specific substitution pattern offers precise reactivity for cross-coupling and functional group transformations.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated aromatic structure.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to build biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for biochemical research.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing of complex, high-value organic compounds.

Basic Information

Product Name	2-(4-Bromo-2-Fluorophenyl)-2-Methylpropanenitrile
CAS No.	749928-77-6
Molecular Formula	C10H9BrFN
Molecular Weight	242.09 g/mol
Synonyms	2-(4-Bromo-2-fluorophenyl)-2-methylpropanenitrile; α-(4-Bromo-2-fluorophenyl)isobutyronitrile; 4-Bromo-2-fluoro-α,α-dimethylbenzeneacetonitrile; 2-Methyl-2-(4-bromo-2-fluorophenyl)propanenitrile; (4-Bromo-2-fluorophenyl)(cyano)dimethylmethane; 749928-77-6; 2-(4-Bromo-2-fluoro-phenyl)-2-methyl-propionitrile
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-2-Fluorophenyl)-2-Methylpropanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.