Description

(11Beta,16Beta)-Pregna-1,4-Diene-3,20-Dione,21-Amino-9-Fluoro-11,17-Dihydroxy-16-Methyl-,Hydrochloride is a high-purity synthetic corticosteroid derivative, specifically engineered for advanced pharmaceutical research and development. This compound is critical for its potent anti-inflammatory and immunosuppressive properties, serving as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of next-generation therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on developing novel treatments for autoimmune disorders, dermatological conditions, and ophthalmic applications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potent topical and systemic corticosteroid APIs.
• Anti-inflammatory Drug Research: Used as a reference standard and active material in preclinical studies for developing new anti-inflammatory medications.
• Immunosuppressant Development: Investigated for its role in creating therapies for autoimmune diseases such as psoriasis, rheumatoid arthritis, and lupus.
• Dermatological Formulations: A key ingredient in the R&D of advanced creams, ointments, and lotions for treating severe eczema, dermatitis, and other skin conditions.
• Ophthalmic Solution Research: Utilized in developing steroid treatments for inflammatory eye diseases, including uveitis and allergic conjunctivitis.
• Analytical Reference Standard: Provides a high-purity benchmark for quality control (QC) and analytical method development (HPLC, LC-MS) in pharmaceutical laboratories.
• Biochemical Research: Employed in studies to understand glucocorticoid receptor interactions and downstream signaling pathways.

Basic Information

Product Name	(11Beta,16Beta)-Pregna-1,4-Diene-3,20-Dione,21-Amino-9-Fluoro-11,17-Dihydroxy-16-Methyl-,Hydrochloride
CAS No.	744254-11-3
Molecular Formula	C22H29F N2O5 • HCl
Molecular Weight	464.94 g/mol (Free base: 428.48 g/mol)
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-Amine Hydrochloride; 21-Amino-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Hydrochloride; Fluorometholone Amine Hydrochloride; Fluorometholone Intermediate; 11β,16β-Epoxy-9α-fluoro-21-(methylamino)pregna-1,4-diene-3,20-dione Hydrochloride (related); 16β-Methyl-9α-fluoro-δ1-hydrocortisone-21-amine Hydrochloride
EINECS	Contact for details

Quality Control

Our (11Beta,16Beta)-Pregna-1,4-Diene-3,20-Dione,21-Amino-9-Fluoro-11,17-Dihydroxy-16-Methyl-,Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.