Description

21-Amino-9-Fluoro-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex steroidal structure. This compound is critical for the research and development of novel corticosteroid-based therapeutics, offering a key building block for targeted drug synthesis. It is primarily sought by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on endocrinology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel corticosteroid and glucocorticoid receptor-targeting drugs.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Utilized in studies investigating steroid hormone receptor binding and signal transduction pathways.
• Process Development: Acts as a critical material for scaling up synthetic routes in process chemistry.

Basic Information

Product Name	21-Amino-9-Fluoro-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione Hydrochloride
CAS No.	744254-10-2
Molecular Formula	C22H29F N2O5 • HCl
Molecular Weight	464.94 g/mol (Free base: 428.48 g/mol)
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Amine Hydrochloride; 21-Amino-9α-fluoro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione Hydrochloride; 21-Aminodexamethasone Hydrochloride (derivative); 21-Amino-9-fluoro-16-methylprednisolone Hydrochloride; 744254-10-2; UNII-8VU5N8U3P9
EINECS	Contact for details

Quality Control

Our 21-Amino-9-Fluoro-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and related substances. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.