Description

1-Propanone, 2,2,3,3,3-Pentafluoro-1-(2-Pyrrolidinyl)- (9Ci) is a specialized fluorinated pyrrolidine derivative, serving as a high-value building block in advanced organic synthesis. Its unique molecular architecture, featuring a pentafluoroacetone moiety linked to a pyrrolidine ring, makes it a critical intermediate for developing novel compounds with tailored properties. This chemical is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to incorporate fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Research: Used to develop novel fluorinated pesticides and herbicides, where the fluorine atoms improve lipophilicity and environmental persistence.
• Material Science: Building block for creating specialty polymers and coatings with enhanced chemical resistance and unique surface properties.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis and organofluorine chemistry.
• Diagnostic Agent Development: Potential intermediate in the creation of fluorinated contrast agents or radiotracers for medical imaging (e.g., PET).
• Academic & Industrial R&D: A valuable reagent for exploring new reaction pathways and creating compound libraries in medicinal chemistry programs.

Basic Information

Product Name	1-Propanone, 2,2,3,3,3-Pentafluoro-1-(2-Pyrrolidinyl)- (9Ci)
CAS No.	742038-20-6
Molecular Formula	C7H8F5NO
Molecular Weight	217.14 g/mol
Synonyms	2,2,3,3,3-Pentafluoro-1-(pyrrolidin-2-yl)propan-1-one; 1-(2-Pyrrolidinyl)-2,2,3,3,3-pentafluoro-1-propanone; Pentafluoro-1-(2-pyrrolidinyl)propanone; 2-Pyrrolidinyl pentafluoroacetone; Fluorinated pyrrolidinyl ketone; α-Pyrrolidinyl pentafluoroacetone; (2-Pyrrolidinyl)-2,2,3,3,3-pentafluoropropanone
EINECS	Contact for details

Quality Control

Our 1-Propanone, 2,2,3,3,3-Pentafluoro-1-(2-Pyrrolidinyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.