Description

1-Bromo-2,5-difluoro-3-nitrobenzene is a high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its precise molecular architecture, featuring bromine, fluorine, and nitro substituents, enables selective functionalization and the introduction of unique electronic properties into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoro and nitro groups contribute to biological activity and selectivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine substituent.
• Nucleophilic Aromatic Substitution: The electron-deficient aromatic ring, activated by fluorine and nitro groups, facilitates nucleophilic substitution reactions for further derivatization.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for screening.

Basic Information

Product Name	1-Bromo-2,5-difluoro-3-nitrobenzene
CAS No.	741721-51-7
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	2,5-Difluoro-3-nitro-1-bromobenzene; 3-Bromo-2,6-difluoronitrobenzene; 1-Bromo-2,5-difluoro-3-nitro-benzene; Benzene, 1-bromo-2,5-difluoro-3-nitro-; 741721-51-7
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,5-difluoro-3-nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.