Description

3-Hydroxy-4-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic intermediate featuring a nitrile group and a hydroxyl substituent. This compound is critical for its role in synthesizing advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development scientists for constructing complex active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in electronic display technologies.
• Organic Synthesis & Research: A versatile reagent for introducing the 3-hydroxy-4-(trifluoromethyl)phenyl moiety into more complex molecular architectures in academic and industrial R&D.
• Advanced Material Development: Employed in the creation of specialty polymers and functional materials with specific optical or electronic properties.

Basic Information

Product Name	3-Hydroxy-4-(Trifluoromethyl)Benzonitrile
CAS No.	731002-50-9
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	4-Cyano-2-(trifluoromethyl)phenol; 2-Hydroxy-5-(trifluoromethyl)benzonitrile; 3-Hydroxy-α,α,α-trifluoro-p-tolunitrile; 5-(Trifluoromethyl)-2-hydroxybenzonitrile; 2-Cyano-5-(trifluoromethyl)phenol; 731002-50-9; 4-(Trifluoromethyl)-3-hydroxybenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.