Description

3-Hydroxy-2-(Trifluoromethyl)Benzonitrile is a versatile fluorinated aromatic intermediate of significant interest in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl group and a trifluoromethyl substituent on a benzonitrile core, makes it a valuable building block for creating molecules with enhanced properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries. It serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those requiring the metabolic stability and lipophilicity imparted by the trifluoromethyl group.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms can improve biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis, especially in cross-coupling and other transition metal-catalyzed reactions.
• Material Science Research: Employed in the development of advanced organic materials, such as liquid crystals or polymers with specific electronic or optical properties.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Hydroxy-2-(Trifluoromethyl)Benzonitrile
CAS No.	731002-48-5
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	2-(Trifluoromethyl)-3-hydroxybenzonitrile; 3-Hydroxy-2-(trifluoromethyl)benzonitrile; 2-Cyano-6-(trifluoromethyl)phenol; 6-(Trifluoromethyl)salicylonitrile; 3-Hydroxy-α,α,α-trifluoro-o-tolunitrile; o-Cyano-α,α,α-trifluoro-m-cresol; 731002-48-5; 2-Trifluoromethyl-3-hydroxybenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy-2-(Trifluoromethyl)Benzonitrile is produced and tested under a strict quality management system. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with exacting customer and research standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.