Description

n-[2-Hydroxy-5-[(1S)-1-Hydroxy-2-[[(1S)-2-(4-Methoxyphenyl)-1-Methylethyl]Amino]Ethyl]Phenyl]Acetamide is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting adrenergic pathways. Pharmaceutical manufacturers and advanced R&D laboratories need this material for its precise chiral configuration, which is essential for ensuring the efficacy and safety of final drug products.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel β-adrenergic receptor agonists and related therapeutic agents.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new chemical entities (NCEs) targeting respiratory and cardiovascular conditions.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in stereoselective organic synthesis due to its defined (S)-configuration centers.
• Reference Standard: Employed as an analytical standard in method development and quality control for drug substance and product testing.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in the custom synthesis of complex molecules for clinical trials.

Basic Information

Item	Details
Product Name	n-[2-Hydroxy-5-[(1S)-1-Hydroxy-2-[[(1S)-2-(4-Methoxyphenyl)-1-Methylethyl]Amino]Ethyl]Phenyl]Acetamide
CAS No.	725719-13-1
Molecular Formula	C20H26N2O4
Molecular Weight	358.44 g/mol
Synonyms	(S)-N-[2-Hydroxy-5-[(1S)-1-Hydroxy-2-[[(1S)-2-(4-Methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]acetamide; (S)-N-(2-Hydroxy-5-((S)-1-hydroxy-2-(((S)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)acetamide; AR Formoterol Impurity; Formoterol Related Compound A; (S,S,S)-Formoterol Impurity; (R,R,R)-Formoterol Impurity Dihydrochloride (stereoisomer); Formoterol EP Impurity A
EINECS	Contact for details

Quality Control

Our n-[2-Hydroxy-5-[(1S)-1-Hydroxy-2-[[(1S)-2-(4-Methoxyphenyl)-1-Methylethyl]Amino]Ethyl]Phenyl]Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical-grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S,S,S-isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.