Description

3-Fluoro-5-Iodobenzonitrile is a versatile halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and iodine atoms on the aromatic ring, which enables selective cross-coupling reactions and facilitates the introduction of complex functional groups. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings for carbon-carbon bond formation.
• Fluorine Chemistry: The fluorine atom provides metabolic stability and influences lipophilicity, making it valuable for medicinal chemistry and drug discovery programs.
• Chemical Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-Fluoro-5-Iodobenzonitrile
CAS No.	723294-75-5
Molecular Formula	C7H3FIN
Molecular Weight	262.01 g/mol
Synonyms	3-Fluoro-5-iodobenzonitrile; 5-Cyano-1-fluoro-3-iodobenzene; 1-Fluoro-3-iodo-5-cyanobenzene; Benzonitrile, 3-fluoro-5-iodo-; 3-Fluoro-5-iodo-benzonitrile; 3-Fluoro-5-iodobenzene carbonitrile; 3-Fluoro-5-iodophenyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Iodobenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.