Description

Morpholine, 4-(Difluoromethyl)- (9Ci) is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique structure, which incorporates a difluoromethyl group onto the morpholine ring, offering valuable electronic and steric properties for modulating the characteristics of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine atoms to improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorinated morpholine core can enhance biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a precursor for designing novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and functional materials that require fluorinated heterocyclic components for specific electronic or surface properties.
• Chemical Biology Probes: Useful for creating tagged molecules and probes to study biological pathways and enzyme mechanisms.

Basic Information

Product Name	Morpholine, 4-(Difluoromethyl)- (9Ci)
CAS No.	721451-45-2
Molecular Formula	C5H9F2NO
Molecular Weight	137.13 g/mol
Synonyms	4-(Difluoromethyl)morpholine; N-(Difluoromethyl)morpholine; Morpholine, N-(difluoromethyl)-; 4-(Difluoromethyl)-morpholine; Difluoromethylmorpholine; N-Difluoromethylmorpholine; 721451-45-2
EINECS	Contact for details

Quality Control

Every batch of Morpholine, 4-(Difluoromethyl)- (9Ci) is produced and controlled under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride/strong alkali chemical properties, ensure proper segregation in storage areas.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.