Description

2-(3,5-Difluorophenyl)Benzonitrile is a high-purity, fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the difluorophenyl moiety is prized for its ability to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved charge transport and thermal stability.
• Cross-Coupling Reactions: The benzonitrile and aryl halide functionalities make it a versatile substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new fluorination methodologies and constructing complex molecular architectures.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Benzonitrile
CAS No.	717101-37-6
Molecular Formula	C13H7F2N
Molecular Weight	215.20 g/mol
Synonyms	2-(3,5-Difluorophenyl)benzonitrile; [1,1'-Biphenyl]-2-carbonitrile, 3',5'-difluoro-; 3',5'-Difluoro[1,1'-biphenyl]-2-carbonitrile; 2-Cyano-3',5'-difluorobiphenyl; (3,5-Difluorophenyl)-2-cyanobenzene
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. The compound is considered light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.