Description

Benzonitrile, 4-(Aminomethyl)-3-Fluoro- (9Ci) CAS NO 701264-00-8 is a high-purity fluorinated aromatic nitrile derivative featuring a reactive aminomethyl substituent. This compound is a critical pharmaceutical intermediate and organic building block for synthesizing complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate a fluorinated aniline moiety into target structures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Advanced Material Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and probe development due to the aminomethyl group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in multi-step custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	Benzonitrile, 4-(Aminomethyl)-3-Fluoro- (9Ci)
CAS No.	701264-00-8
Molecular Formula	C8H7FN2
Molecular Weight	150.16 g/mol
Synonyms	3-Fluoro-4-(aminomethyl)benzonitrile; 4-(Aminomethyl)-3-fluorobenzonitrile; 3-Fluoro-4-cyanobenzylamine; 4-Cyano-2-fluorobenzylamine; (3-Fluoro-4-cyanophenyl)methanamine; 2-Fluoro-4-(aminomethyl)benzonitrile; 701264-00-8; 4-Aminomethyl-3-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 4-(Aminomethyl)-3-Fluoro- adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for critical synthesis. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support development and commercial projects with research-grade to cGMP-grade material as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.