Description

8-Acetyl-10-((3-Amino-3,5-Dideoxy-α-D-Ribofuranosyl)Oxy)-7,8,9,10- Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-5,12-Naphthacenedione Hydrochloride, (8S-Cis)- is a high-purity, semi-synthetic anthracycline derivative of significant interest in advanced pharmaceutical research and development. Its core value lies in its potential as a key intermediate or active pharmaceutical ingredient (API) for novel oncology therapeutics, leveraging the potent biological activity of the anthracycline scaffold. This compound is essential for research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis and evaluation of next-generation anticancer agents. The CAS number for this compound is provided separately in the basic information below.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the multi-step synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, structure-activity relationships (SAR), and cytotoxicity against various cancer cell lines.
• API Development: Serves as a building block for the development of new Active Pharmaceutical Ingredients (APIs) targeting DNA intercalation and topoisomerase II inhibition.
• Preclinical Studies: Essential for in vitro and in vivo preclinical testing to evaluate the efficacy, pharmacokinetics, and safety profiles of potential drug candidates.
• Process Chemistry: Used by process chemists to develop and optimize scalable, cost-effective, and robust synthetic routes for complex pharmaceutical molecules.
• Reference Standard: High-purity grade suitable for use as an analytical reference standard in quality control (QC) and regulatory submissions.

Basic Information

Item	Details
Product Name	8-Acetyl-10-((3-Amino-3,5-Dideoxy-α-D-Ribofuranosyl)Oxy)-7,8,9,10- Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-5,12-Naphthacenedione Hydrochloride, (8S-Cis)-
CAS No.	79867-86-0
Molecular Formula	C26H28NO11 · HCl
Molecular Weight	582.0 g/mol (approx., for free base; hydrochloride salt weight varies)
Synonyms	4'-O-Acetyl-11-deoxy-13-dihydrodaunorubicin hydrochloride; 4'-O-Acetyladriamycin-14-hydrochloride; 4'-O-Acetyladriamycin-14-HCl; 4'-O-Acetyladriamycin hydrochloride; 4'-O-Acetyladriamycin HCl; 4'-O-Acetyl-13-dihydrodaunorubicin hydrochloride; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Acetyl-10-((3-Amino-3,5-Dideoxy-α-D-Ribofuranosyl)Oxy)-7,8,9,10- Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-5,12-Naphthacenedione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, to ensure it meets stringent specifications suitable for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark environment to maintain stability and potency. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red-orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.