Description

Loratadine CAS NO 79794-75-5 is a potent, long-acting tricyclic antihistamine that selectively antagonizes peripheral H1 receptors. This compound is crucial for the development of non-sedating allergy relief medications, offering significant therapeutic benefits over earlier generation antihistamines. It is primarily required by pharmaceutical manufacturers and R&D facilities for the formulation of tablets, syrups, and orally disintegrating tablets to treat seasonal allergic rhinitis, chronic idiopathic urticaria, and other allergic conditions.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of prescription and over-the-counter (OTC) non-drowsy antihistamine medications.
• Tablet Formulation: Direct compression or wet granulation for standard and fast-dissolving oral tablets.
• Oral Liquid/Syrup Production: Used in pediatric and geriatric-friendly liquid formulations for systemic allergy treatment.
• Combination Drug Therapy: Combined with decongestants like pseudoephedrine in fixed-dose combination products for comprehensive allergy symptom relief.
• Veterinary Pharmaceuticals: Application in veterinary medicine for managing allergic reactions in animals.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC/UV assay development and validation.
• Research & Development: Used in preclinical and clinical studies for developing new allergy therapeutics and exploring novel drug delivery systems.

Basic Information

Item	Detail
Product Name	Loratadine
CAS No.	79794-75-5
Molecular Formula	C22H23ClN2O2
Molecular Weight	382.88 g/mol
Synonyms	Ethyl 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate; Claritin (Brand Name); SCH 29851; Fristamin; Lisino; Lorfast; Alaver; Clarityn; Lora TAB; Loradamed
EINECS	Contact for details

Quality Control

Our Loratadine is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including identification, assay, and impurity profiling to ensure high purity and consistent performance. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and regulatory support for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry, well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Particle Size Distribution	Upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.