Description

3-Bromo-4-Fluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents on a benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic systems for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the bromo and fluoro groups can enhance binding affinity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, enabling novel reaction pathways.
• Material Science Research: Employed in the synthesis of monomers and functional units for advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Item	Details
Product Name	3-Bromo-4-Fluorobenzonitrile
CAS No.	79630-23-2
Molecular Formula	C7H3BrFN
Molecular Weight	200.01 g/mol
Synonyms	4-Fluoro-3-bromobenzonitrile; 3-Bromo-4-fluorobenzene carbonitrile; 2-Bromo-1-fluoro-4-cyanobenzene; 1-Bromo-2-fluoro-4-cyanobenzene; Benzonitrile, 3-bromo-4-fluoro-; 79630-23-2 (CAS); 3-Br-4-F-PhCN
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Fluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 70 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.