Description

Betamethasone 9,11-Epoxide 17-Propionate is a key synthetic steroid intermediate, specifically a derivative of betamethasone. This compound is valued for its role in the synthesis of more complex corticosteroid APIs, offering a critical building block for pharmaceutical manufacturing. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on developing anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry research for developing novel steroid-based therapeutics with modified pharmacokinetic profiles.
• Process Chemistry: Serves as a defined starting material or intermediate in scale-up and process optimization for GMP manufacturing.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.

Basic Information

Product Name	Betamethasone 9,11-Epoxide 17-Propionate
CAS No.	79578-39-5
Molecular Formula	C26H35FO6
Molecular Weight	462.56 g/mol
Synonyms	9,11β-Epoxy-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 9β,11β-Epoxy-16β-methyl-17α-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Betamethasone 9β,11β-Epoxide 17-propionate; (11β,16β)-9,11-Epoxy-17-(1-oxopropoxy)-16-methylpregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Betamethasone 9,11-Epoxide 17-Propionate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.