Description

1,3-Difluoro-2-Methyl-4-Nitrobenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic positioning of fluorine and nitro substituents, which enable precise molecular modifications critical for developing high-performance materials and active compounds. This intermediate is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate difluoromethylbenzene motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorinated aromatic core to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or unique surface properties.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of advanced colorants and fluorinated dyes.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures in medicinal chemistry.

Basic Information

Product Name	1,3-Difluoro-2-Methyl-4-Nitrobenzene
CAS No.	79562-49-5
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-Methyl-1,3-difluoro-4-nitrobenzene; 4-Nitro-1,3-difluoro-2-methylbenzene; 1,3-Difluoro-2-methyl-4-nitro-benzene; 2,4-Difluoro-3-methylnitrobenzene; 3-Methyl-2,4-difluoronitrobenzene; Benzene, 1,3-difluoro-2-methyl-4-nitro-; 79562-49-5
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-2-Methyl-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.