Description

Levocabastine CAS NO 79516-68-0 is a potent and selective histamine H1-receptor antagonist belonging to the chemical class of piperidinecarboxylic acid derivatives. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced ophthalmic and nasal formulations. It is primarily required by pharmaceutical manufacturers and R&D institutions developing next-generation anti-allergic treatments.

Application

• Primary Active Pharmaceutical Ingredient (API) in prescription ophthalmic solutions for allergic conjunctivitis.
• Key component in nasal spray formulations for the treatment of seasonal and perennial allergic rhinitis.
• Reference standard in analytical laboratories for quality control and method validation of anti-allergic products.
• Intermediate in the research and development of novel histamine H1-receptor antagonists.
• Used in clinical studies and pharmacokinetic research related to topical antihistamine efficacy.
• Essential material for compounding pharmacies specializing in custom allergy medications.

Basic Information

Product Name	Levocabastine
CAS No.	79516-68-0
Molecular Formula	C26H29FN2O3
Molecular Weight	420.52 g/mol
Synonyms	Levocabastine Hydrochloride; (3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylisonipecotic Acid; R-50547; Livostin (brand name); Livocab (brand name); (-)-CAB; (3S,4R)-Levocabastine
EINECS	Contact for details

Quality Control

Our Levocabastine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent pharmacopeial standards for identity, purity, and potency. Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological limits are provided and traceable to certified reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Microbial Limits	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.