Description

2-Hydroxyaclacinomycin A is a chemically modified derivative of the anthracycline antibiotic aclacinomycin A. This compound is valued for its role as a key intermediate and reference standard in pharmaceutical research and development, particularly in the study of anticancer agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery and biochemical analysis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used as a reference standard in studies investigating the structure-activity relationships (SAR) of anthracycline antibiotics.
• Oncology R&D: Employed in in vitro and in vivo research to explore mechanisms of action, efficacy, and toxicity profiles of modified anthracyclines.
• Analytical Standard: Provides a high-purity benchmark for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical laboratories.
• Academic Research: Utilized in university and institutional labs for fundamental research on DNA intercalation and topoisomerase inhibition.

Basic Information

Product Name	2-Hydroxyaclacinomycin A
CAS No.	79127-36-9
Molecular Formula	C42H53NO16
Molecular Weight	827.87 g/mol
Synonyms	2'-Hydroxyaclacinomycin A; 2'-OH-Aclacinomycin A; 2'-Hydroxyaklavinone; Aclacinomycin A, 2'-hydroxy-; 7-O-(2,6-Dideoxy-4-O-((2S,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-α-L-lyxo-hexopyranosyl)-2'-hydroxyaklavinone
EINECS	Contact for details

Quality Control

Our 2-Hydroxyaclacinomycin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.