Description

(-)-Carazolol CAS NO 78859-33-3 is a high-purity, enantiomerically pure β-adrenergic receptor antagonist (β-blocker). This compound is of significant value as a potent and selective pharmacological research tool for studying adrenergic signaling pathways. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the development of cardiovascular therapeutics and receptor-specific biochemical assays.

Application

• Pharmacological Research: A key reference standard and active agent in studies of β-1 and β-2 adrenergic receptor function and blockade.
• Biochemical Assay Development: Used in the development and validation of high-throughput screening (HTS) assays for drug discovery programs targeting G-protein-coupled receptors (GPCRs).
• Metabolite Identification: Serves as a precursor or standard for investigating the metabolic pathways of β-blocking agents in vitro.
• Analytical Method Development: Employed as a certified reference material (CRM) for calibrating HPLC, LC-MS, and other analytical systems in pharmaceutical quality control.
• Preclinical Studies: Utilized in animal models to investigate the effects of β-adrenergic antagonism on cardiovascular parameters.
• Fine Chemical Synthesis: An advanced intermediate or chiral building block for the synthesis of more complex, targeted therapeutic molecules.

Basic Information

Product Name	(-)-Carazolol
CAS No.	78859-33-3
Molecular Formula	C18H22N2O2
Molecular Weight	298.38 g/mol
Synonyms	(-)-1-(Carbazol-4-yloxy)-3-[(2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; (S)-(-)-Carazolol; Carazolol, (-)-; Levocarazolol; BM 51052; BMD 51052; KAR 2017; NSC 326023; 4-[2-Hydroxy-3-[(2-(2-methoxyphenoxy)ethyl]amino]propoxy]carbazole
EINECS	Contact for details

Quality Control

Our (-)-Carazolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.