Description

11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate) CAS NO 78806-74-3 is a high-purity synthetic corticosteroid intermediate, specifically a succinate ester derivative of a prednisolone analog. This compound is valued for its role as a critical building block in the synthesis of advanced anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of specialized steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potent topical and systemic corticosteroids.
• Anti-inflammatory Drug Development: Used in research and production of APIs for treating conditions like dermatitis, arthritis, and asthma.
• Immunosuppressant Synthesis: Serves as a starting material for drugs that modulate the immune system.
• Steroid Prodrug Manufacturing: The succinate ester group enhances solubility for injectable formulations.
• Reference Standard: Used in analytical laboratories for quality control and method development.
• Biochemical Research: Tool compound for studying glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Item	Detail
Product Name	11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate)
CAS No.	78806-74-3
Molecular Formula	C28H36O9
Molecular Weight	516.59 g/mol
Synonyms	Prednisolone 21-Hydrogen Succinate 16,17-Acetonide; Prednisolone 21-Hemisuccinate 16,17-Acetonide; 16α,17-Isopropylidenedioxyprednisolone 21-Hemisuccinate; 11β,21-Dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione 21-(hydrogen butanedioate); Prednisolone Acetonide 21-Hemisuccinate; (11β)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione 21-(hydrogen succinate)
EINECS	Contact for details

Quality Control

Our 11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing including HPLC for purity, identity confirmation by IR and NMR, and control of related substances to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.