Description

Desonide Isobutyrate is a synthetic corticosteroid ester derivative, valued for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for the development of advanced topical dermatological treatments. It is primarily required by pharmaceutical manufacturers and R&D facilities focused on creating effective solutions for inflammatory skin conditions.

Application

• Active Pharmaceutical Ingredient (API) in topical creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Key Intermediate in the synthesis of more complex corticosteroid derivatives for enhanced therapeutic profiles.
• Research & Development material for pharmacological studies on glucocorticoid receptor activity and anti-inflammatory mechanisms.
• Formulation Development for novel drug delivery systems, including gels and medicated patches.
• Veterinary Pharmaceutical applications in topical preparations for animal skin care.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Desonide Isobutyrate
CAS No.	78806-61-8
Molecular Formula	C26H36O7
Molecular Weight	460.56 g/mol
Synonyms	Desonide 21-Isobutyrate; 11β,21-Dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione 21-Isobutyrate; Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, 21-(2-methylpropanoate); Desonide Isobutyrate Ester; Desonide 17-Valerate (common misnomer); 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-isobutyrate (IUPAC-like); Desoximetasone related compound (structural analog).
EINECS	Contact for details

Quality Control

Our Desonide Isobutyrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.