Description

11Alpha,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is a synthetic corticosteroid derivative, specifically a methylated and hydroxylated pregnadiene. This compound is of significant interest in pharmaceutical research and development due to its structural relationship to potent anti-inflammatory agents. It serves as a critical pharmaceutical intermediate or reference standard for the synthesis and analytical characterization of advanced steroid-based therapeutics. Target users include R&D laboratories, pharmaceutical manufacturers, and fine chemical suppliers engaged in steroid chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of steroid APIs and finished products.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor binding affinity, metabolic pathways, and structure-activity relationships (SAR).
• Process Development: Serves as a benchmark compound for optimizing fermentation or chemical synthesis routes in scale-up production.

Basic Information

Item	Detail
Product Name	11Alpha,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	78761-59-8
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	16α-Methylprednisolone; 16α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; 11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 16α-Methyl-δ1-hydrocortisone; 16α-Methylprednisolone (11β,17α,21-Trihydroxy form)
EINECS	Contact for details

Quality Control

Our 11Alpha,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing results from HPLC, NMR, and other relevant pharmacopeial tests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere or with appropriate desiccants to maintain stability. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.