Description

Diethyl (3-Fluoro-4-Nitrophenyl)Methylmalonate is a high-purity fluorinated organic intermediate with a malonate ester core structure. This compound is valued for its role as a versatile building block in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty fine chemicals. The product is supplied to meet the stringent quality and consistency requirements of industrial-scale synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atom and nitro group are critical for biological activity.
• Fine Chemical Production: Serves as a specialized building block for creating complex organic molecules used in material science and chemical research.
• Research & Development: Employed in academic and industrial R&D labs for method development and exploring new synthetic pathways in organic chemistry.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integrated into multi-step synthesis processes for the commercial production of fluorinated APIs.

Basic Information

Product Name	Diethyl (3-Fluoro-4-Nitrophenyl)Methylmalonate
CAS No.	78543-06-3
Molecular Formula	C₁₄H₁₆FNO₆
Molecular Weight	313.28 g/mol
Synonyms	Diethyl (3-fluoro-4-nitrophenyl)methylmalonate; Diethyl (3-Fluoro-4-Nitrobenzyl)malonate; Methyl(3-fluoro-4-nitrophenyl)malonic Acid Diethyl Ester; Propanedioic acid, 2-(3-fluoro-4-nitrophenyl)-, 1,3-diethyl ester; 1,3-Diethyl 2-(3-fluoro-4-nitrophenyl)propanedioate; Diethyl (3-Fluoro-4-Nitrobenzyl)malonate; 78543-06-3
EINECS	Contact for details

Quality Control

Our Diethyl (3-Fluoro-4-Nitrophenyl)Methylmalonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in cGMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flames. For long-term storage, consider maintaining the material under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.