Description

Chlorpheniramine is a first-generation alkylamine antihistamine known for its potent H1-receptor antagonism. This compound is a critical active pharmaceutical ingredient (API) valued for its effectiveness in managing allergic conditions and its role as a foundational component in various therapeutic formulations. It is essential for manufacturers in the pharmaceutical industry producing antihistamine medications, including tablets, syrups, and combination cold/flu remedies. Chlorpheniramine CAS NO 78539-96-5 is supplied under stringent quality controls to ensure reliability for global B2B supply chains.

Application

• Pharmaceutical API: Primary active ingredient in prescription and over-the-counter (OTC) antihistamine medications.
• Allergy Relief Formulations: Used in tablets, capsules, and syrups for the symptomatic treatment of hay fever, allergic rhinitis, conjunctivitis, and urticaria.
• Cold and Flu Preparations: A key component in multi-symptom relief formulas, often combined with analgesics, decongestants, and antitussives.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for managing allergic reactions and pruritus in animals.
• Research and Development: Serves as a reference standard and building block in pharmacological research and new drug development.

Basic Information

Product Name	Chlorpheniramine
CAS No.	78539-96-5
Molecular Formula	C16H19ClN2
Molecular Weight	274.79 g/mol
Synonyms	Chlorpheniramine Maleate (common salt form); Chlorphenamine; Piriton; Chlor-Trimeton; 1-(4-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; Histafen; Teldrin
EINECS	Contact for details

Quality Control

Our Chlorpheniramine is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality assurance protocols align with GMP (Good Manufacturing Practice) guidelines. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. We ensure compliance with relevant pharmacopeial standards, including USP and EP monographs where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.