Description

Lhrh,(N)-Ac-(4-Cl-Phe)(1)-(4-Cl-Phe)(2)-Trp(3)-Phe(6)-Alanh2(10)- CAS NO 78493-58-0 is a synthetic, modified peptide analog of Luteinizing Hormone-Releasing Hormone (LHRH). This compound is engineered for enhanced stability and specific receptor binding affinity, making it a critical research tool and a potential precursor for therapeutic development. It is primarily utilized by pharmaceutical researchers, biotech companies, and academic institutions focused on endocrinology, oncology, and advanced peptide chemistry.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel hormone therapies and targeted cancer treatments.
• Endocrinology Studies: Used in vitro and in vivo to study the modulation of the hypothalamic-pituitary-gonadal axis, receptor binding kinetics, and signal transduction pathways.
• Oncology Research: Investigated for its potential in the development of targeted therapies for hormone-dependent cancers, such as prostate and breast cancer.
• Peptide Chemistry & Conjugation: Acts as a sophisticated building block for creating more complex peptide-drug conjugates or for structure-activity relationship (SAR) studies.
• Biochemical Assay Development: Employed as a high-purity calibrant or ligand in the development of diagnostic assays and screening platforms.

Basic Information

Product Name	Lhrh,(N)-Ac-(4-Cl-Phe)(1)-(4-Cl-Phe)(2)-Trp(3)-Phe(6)-Alanh2(10)- CAS NO 78493-58-0
CAS No.	78493-58-0
Molecular Formula	C64H78Cl2N14O12
Molecular Weight	1257.3 g/mol
Synonyms	Ac-D-4-Cl-Phe-D-4-Cl-Phe-Trp-Ser-Tyr-D-Phe-Leu-Arg-Pro-Ala-NH2; LHRH Antagonist Analog; Modified Luteinizing Hormone-Releasing Hormone Peptide; [Ac-D-4-Cl-Phe1, D-4-Cl-Phe2, Trp3, D-Phe6, Ala10]-LHRH; Gonadorelin Analog; GnRH Antagonist Derivative; Peptide 78493-58-0
EINECS	Contact for details

Quality Control

Our Lhrh,(N)-Ac-(4-Cl-Phe)(1)-(4-Cl-Phe)(2)-Trp(3)-Phe(6)-Alanh2(10)- CAS NO 78493-58-0 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide Certificates of Analysis (COA) with detailed chromatographic data, ensuring traceability and compliance with research-grade standards. Specifications can be aligned with cGMP guidelines for advanced preclinical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere. Keep containers tightly sealed in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.