Description

Locicortolone is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, identified by CAS NO 78467-68-2. This compound is a critical intermediate in the synthesis of advanced topical and systemic pharmaceutical formulations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel anti-inflammatory drugs, dermatological treatments, and specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Development: Used in R&D for creating new topical creams, ointments, and lotions for treating skin conditions like eczema, psoriasis, and dermatitis.
• Immunosuppressive Agent Research: Serves as a precursor in studies targeting autoimmune disorders and allergic reactions.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory treatments for animals.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: A tool compound for investigating glucocorticoid receptor activity and related metabolic pathways.

Basic Information

Item	Detail
Product Name	Locicortolone
CAS No.	78467-68-2
Molecular Formula	C24H31FO6
Molecular Weight	434.50 g/mol
Synonyms	Locicortolone; 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9α-Fluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; Fluocortin Butyl; SH K 203; SHK-203; Fluocortin butyl ester (related compound); Pivalone (trade name variant).
EINECS	Contact for details

Quality Control

Our Locicortolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.