Description

(1R)-1,2,3,4,6,11-Hexahydro-2α,5,7-Trihydroxy-6,11-Dioxo-2-(2-Oxopropyl)-1β-Naphthacenecarboxylic Acid Methyl Ester is a high-purity, complex tetracycline derivative intermediate of significant importance in pharmaceutical synthesis. This compound matters as a critical building block for the development of novel antibiotics and other therapeutic agents, offering precise stereochemistry and functional groups for advanced research and manufacturing. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the synthesis of next-generation tetracycline-class antibiotics and specialized chemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel semi-synthetic tetracycline antibiotics and their analogs.
• Antibiotic Research & Development: Serves as a core scaffold for medicinal chemistry programs targeting bacterial resistance mechanisms.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex, high-value molecules for biological testing.
• Biochemical Probes: Potential use in developing labeled compounds for studying bacterial protein synthesis and mechanism-of-action research.
• Academic Research: Employed in university and institutional labs for studying structure-activity relationships (SAR) within the tetracycline family.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(1R)-1,2,3,4,6,11-Hexahydro-2α,5,7-Trihydroxy-6,11-Dioxo-2-(2-Oxopropyl)-1β-Naphthacenecarboxylic Acid Methyl Ester
CAS No.	78173-94-1
Molecular Formula	C24H22O9
Molecular Weight	454.43 g/mol
Synonyms	Methyl (1R)-1,2,3,4,6,11-hexahydro-2α,5,7-trihydroxy-6,11-dioxo-2-(2-oxopropyl)-1β-naphthacenecarboxylate; 2-(2-Oxopropyl)-2α,5,7-trihydroxy-1β-methyl 1,2,3,4,6,11-hexahydro-6,11-dioxonaphthacene-1-carboxylate; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline methyl ester derivative; Tetracycline derivative intermediate; 78173-94-1; (1R)-Methyl 1,2,3,4,6,11-hexahydro-2α,5,7-trihydroxy-6,11-dioxo-2-(2-oxopropyl)-1β-naphthacenecarboxylate
EINECS	Contact for details

Quality Control

Our (1R)-1,2,3,4,6,11-Hexahydro-2α,5,7-Trihydroxy-6,11-Dioxo-2-(2-Oxopropyl)-1β-Naphthacenecarboxylic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting research and pharmaceutical-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to Orange Powder
Identification (IR)	Conforms to Reference Spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.