Description

6 β-Hydroxybetamethasone 17-Propionate is a synthetic corticosteroid derivative, specifically a key intermediate in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). This compound matters for its role in pharmaceutical research and development, enabling the creation of potent anti-inflammatory and immunosuppressive agents. It is primarily needed by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on developing advanced corticosteroid therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced topical and systemic corticosteroid APIs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new anti-inflammatory drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for betamethasone-derived pharmaceuticals.
• Dermatological Preparations: A precursor in the synthesis of APIs used in creams, ointments, and lotions for treating skin conditions like eczema and psoriasis.

Basic Information

Product Name	6 β-Hydroxybetamethasone 17-Propionate
CAS No.	78144-00-0
Molecular Formula	C26H37FO7
Molecular Weight	480.57 g/mol
Synonyms	6β-Hydroxybetamethasone 17-propionate; 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate 6β-ol; Betamethasone 17-propionate, 6β-hydroxy-; 6β-Hydroxy-9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate
EINECS	Contact for details

Quality Control

Our 6 β-Hydroxybetamethasone 17-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or pharmacopeial (e.g., USP, EP) standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.