Description

Nafarelin Acetate is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) with potent agonist activity. This high-purity peptide is critical for advanced pharmaceutical research and development, particularly in endocrinology and oncology. It is primarily utilized by pharmaceutical manufacturers and research institutions developing treatments for hormone-dependent conditions such as endometriosis, central precocious puberty, and prostate cancer.

Application

• Pharmaceutical Active Ingredient (API): Core component in injectable formulations for the treatment of endometriosis and central precocious puberty.
• Oncology Research: Used in clinical studies and therapeutic development for hormone-sensitive cancers, including prostate and breast cancer.
• Endocrinology Research: A key tool for studying the hypothalamic-pituitary-gonadal axis, GnRH receptor activity, and hormonal regulation.
• Veterinary Pharmaceuticals: Employed in fertility control and the treatment of reproductive disorders in animals.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical manufacturing.
• Peptide Chemistry & Synthesis: Used as a building block or intermediate in the synthesis of more complex peptide-based therapeutics.

Basic Information

Product Name	Nafarelin Acetate
CAS No.	78115-72-7
Molecular Formula	C66H83N17O13 • (C2H4O2)x
Molecular Weight	1322.5 g/mol (free base)
Synonyms	Nafarelin Acetate; 6-D-(2-Naphthyl)alanine-GnRH; [6-D-(2-Nal)]LHRH; LHRH agonist (6-D-(2-Nal)); Gonadorelin (6-D-(2-Naphthyl-Ala)) analog; RS-94991-298; Synarel (Brand Name); Nafarelin
EINECS	Contact for details

Quality Control

Our Nafarelin Acetate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, peptide content determination, and identity confirmation by mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Peptide Content	≥ 80.0%
Acetic Acid Content	4.0% - 12.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Specific Rotation	-30° to -40° (c=1 in 1% acetic acid)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.