Description

5-Fluoro-2-Methylbenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and nitrile group are crucial for modulating biological activity and physicochemical properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating molecules with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine substituent enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and the behavior of fluorinated arenes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	5-Fluoro-2-Methylbenzonitrile
CAS No.	77532-79-7
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	2-Methyl-5-fluorobenzonitrile; 5-Fluoro-o-tolunitrile; 2-Cyano-4-fluorotoluene; 4-Fluoro-2-methylbenzonitrile; Benzonitrile, 5-fluoro-2-methyl-; 5-Fluoro-2-methylbenzenecarbonitrile; 2-Methyl-5-fluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.