Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxy-N1-[2-[(2-Hydroxyethyl)Amino]Ethyl]Bleomycinamide is a structurally complex and highly potent bleomycin derivative, representing a key intermediate in advanced pharmaceutical research. Its primary value lies in its role as a critical precursor for the synthesis of novel antitumor agents, enabling the development of targeted chemotherapeutics with potentially improved efficacy and safety profiles. This compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation bleomycin-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) of bleomycin analogs.
• Antitumor Agent Development: A critical precursor for creating novel compounds designed to target specific cancer cell mechanisms with reduced systemic toxicity.
• Academic & Institutional Research: Employed in university and research institute labs for studying DNA cleavage and radiomimetic properties.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for complex glycopeptide antibiotics in pilot and commercial manufacturing.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxy-N1-[2-[(2-Hydroxyethyl)Amino]Ethyl]Bleomycinamide
CAS No.	77368-78-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bleomycinamide derivative; 19-Demethyl-bleomycin derivative; Talopyranosyl bleomycinamide; BLM derivative; Bleomycin intermediate; N1-[2-[(2-Hydroxyethyl)amino]ethyl]-13-[(4-amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-19-demethyl-12-hydroxybleomycinamide; 77368-78-6
EINECS	Contact for details

Quality Control

Our 13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxy-N1-[2-[(2-Hydroxyethyl)Amino]Ethyl]Bleomycinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.